Fetal and trophoblast PI3K p110α have distinct roles in regulating resource supply to the growing fetus in mice.

ABSTRACT: Studies suggest that placental nutrient supply adapts according to fetal demands. However, signaling events underlying placental adaptations remain unknown. Here we demonstrate that phosphoinositide 3-kinase p110α in the fetus and the trophoblast interplay to regulate placental nutrient supply and fetal growth. Complete loss of fetal p110α caused embryonic death, whilst heterozygous loss resulted in fetal growth restriction and impaired placental formation and nutrient transport. Loss of trophoblast p110α resulted in viable fetuses, abnormal placental development and a failure of the placenta to transport sufficient nutrients to match fetal demands for growth. Using RNA-seq we identified genes downstream of p110α in the trophoblast that are important in adapting placental phenotype. Using

SUBMITTER: Lopez-Tello J 

PROVIDER: S-EPMC6634971 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature