Disparities in insulin resistance between black and white adults in the United States: The role of lifespan stress exposure.

ABSTRACT:

Background

Disparities in insulin resistance between Black and White adults in the United States are well documented, yet relatively little is known about the psychosocial or biological antecedents of these inequities. The current study examined childhood adversity and contemporaneous psychosocial stressors in adulthood as possible mediators of the racial disparity in insulin resistance. Inflammatory and hypothalamic-pituitary adrenal (HPA) axis mechanisms implicated in associations between lifespan stress exposure and insulin resistance were also considered.

Methods

Data were derived from the biomarker component of the Midlife in the United States Study (N = 1170, 20% Black, 56% female, Mean age = 54.7 years, SD = 11.6). A homeostatic model assessment of insulin resistance

SUBMITTER: Fuller-Rowell TE 

PROVIDER: S-EPMC6635018 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature