Adrenal morphology and associated comorbidities in congenital adrenal hyperplasia.

ABSTRACT:

Objective

Adrenonodular hyperplasia and tumour formation are potential long-term complications of congenital adrenal hyperplasia (CAH) with little known regarding the clinical implications. Our aim was to describe volumetric adrenal morphology and determine the association between radiological findings and comorbidities in adults with classic CAH.

Design

This was a cross-sectional study of 88 patients (mean age 29.2 ± 13 years, 47 females) with classic CAH seen in a tertiary referral centre.

Methods

CT imaging, performed at study entry or when reaching adulthood, was used to create 3-dimensional volumetric models. Clinical, genetic and hormonal evaluations were collected and correlated with adrenal morphology and tumour formation.

Results

Over one-third of the

SUBMITTER: El-Maouche D 

PROVIDER: S-EPMC6635023 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature