RAId: Knowledge-Integrated Proteomics Web Service with Accurate Statistical Significance Assignment.

ABSTRACT: Mass spectrometry-based proteomics starts with identifications of peptides and proteins, which provide the bases for forming the next-level hypotheses whose "validations" are often employed for forming even higher level hypotheses and so forth. Scientifically meaningful conclusions are thus attainable only if the number of falsely identified peptides/proteins is accurately controlled. For this reason, RAId continued to be developed in the past decade. RAId employs rigorous statistics for peptides/proteins identification, hence assigning accurate P-values/E-values that can be used confidently to control the number of falsely identified peptides and proteins. The RAId web service is a versatile tool built to identify peptides and proteins from tandem mass spectrometry data. Not only recogniz

SUBMITTER: Ogurtsov AY 

PROVIDER: S-EPMC6635056 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature