Measuring and Analyzing Length of Stay in Critical Care Trials.

ABSTRACT:

Background

In randomized clinical trials among critically ill patients, it is uncertain how choices regarding the measurement and analysis of nonmortal outcomes measured in terms of duration, such as intensive care unit (ICU) length of stay (LOS), affect studies' conclusions.

Objectives

Assess the definitions and analytic methods used for ICU LOS analyses in published randomized clinical trials.

Research design

This is a systematic review and statistical simulation study.

Results

Among the 80 of 150 trials providing sufficient information regarding the chosen definition of ICU LOS, 3 different start times (ICU admission, trial enrollment/randomization, receipt of intervention) and 2 end times (discharge readiness, actual discharge) were used. In roughly three q

SUBMITTER: Harhay MO 

PROVIDER: S-EPMC6635104 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature