Creation and analysis of biochemical constraint-based models using the COBRA Toolbox v.3.0.

ABSTRACT: Constraint-based reconstruction and analysis (COBRA) provides a molecular mechanistic framework for integrative analysis of experimental molecular systems biology data and quantitative prediction of physicochemically and biochemically feasible phenotypic states. The COBRA Toolbox is a comprehensive desktop software suite of interoperable COBRA methods. It has found widespread application in biology, biomedicine, and biotechnology because its functions can be flexibly combined to implement tailored COBRA protocols for any biochemical network. This protocol is an update to the COBRA Toolbox v.1.0 and v.2.0. Version 3.0 includes new methods for quality-controlled reconstruction, modeling, topological analysis, strain and experimental design, and network visualization, as well as network integ

SUBMITTER: Heirendt L 

PROVIDER: S-EPMC6635304 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature