Single Nucleotide Polymorphisms of FCRL3 in Iranian Patients with Behcet's Disease.

ABSTRACT:

Background

Both genetic and environmental factors influence, susceptibility to autoimmune disorders including Behcet's disease (BD). FCRL3 (Fc receptor like 3 genes), a novel immunoregulatory gene, has recently been reported as a new promising candidate gene for general autoimmunity. This study was conducted to explore the potential association of FCRL3 polymorphisms with BD.

Methods

This study was conducted from 2010 to 2015 in Tehran University of Medical Sciences, Tehran, Iran. Four single-nucleotide polymorphisms of FCRL3 (rs7528684, rs11264799, rs945635, and rs3761959) were genotyped in 220 patients and 220 healthy controls. Typing of the polymorphisms in this case-control study was carried out using polymerase chain reaction-restriction fragment length polymorphism ana

SUBMITTER: Shahram F 

PROVIDER: S-EPMC6635340 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature