Bisphenol A Regulates Sodium Ramp Currents in Mouse Dorsal Root Ganglion Neurons and Increases Nociception.

ABSTRACT: 17β-Estradiol mediates the sensitivity to pain and is involved in sex differences in nociception. The widespread environmental disrupting chemical bisphenol A (BPA) has estrogenic activity, but its implications in pain are mostly unknown. Here we show that treatment of male mice with BPA (50 µg/kg/day) during 8 days, decreases the latency to pain behavior in response to heat, suggesting increased pain sensitivity. We demonstrate that incubation of dissociated dorsal root ganglia (DRG) nociceptors with 1 nM BPA increases the frequency of action potential firing. SCN9A encodes the voltage-gated sodium channel Na_v1.7, which is present in DRG nociceptors and is essential in pain signaling. Na_v1.7 and other voltage-gated sodium channels in mouse DRG are considered threshol

SUBMITTER: Soriano S 

PROVIDER: S-EPMC6635372 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature