Ontology highlight
ABSTRACT:
SUBMITTER: Argemi J
PROVIDER: S-EPMC6635373 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Nature communications 20190716 1
Alcoholic hepatitis (AH) is a life-threatening condition characterized by profound hepatocellular dysfunction for which targeted treatments are urgently needed. Identification of molecular drivers is hampered by the lack of suitable animal models. By performing RNA sequencing in livers from patients with different phenotypes of alcohol-related liver disease (ALD), we show that development of AH is characterized by defective activity of liver-enriched transcription factors (LETFs). TGFβ1 is a key ...[more]