Hypoxia-induced epithelial-mesenchymal transition and fibrosis for the development of breast capsular contracture.

ABSTRACT: Fibrosis has been considered as a major cause of capsular contracture. Hypoxia has widely emerged as one of the driving factors for fibrotic diseases. The aim of this study was to examine the association between hypoxia-induced fibrosis and breast capsular contracture formation. Fibrosis, epithelial-mesenchymal transition (EMT), expression levels of hypoxia-inducible factor-1α (HIF-1α), vimentin, fibronectin, and matrix metalloproteinase-9 (MMP-9) in tissues from patients with capsular contracture were determined according to the Baker classification system. Normal breast skin cells in patients with capsular contracture after implant-based breast surgery and NIH3T3 mouse fibroblasts were cultured with cobalt chloride (CoCl₂) to mimic hypoxic conditions. Treatment responses were

SUBMITTER: Kuo YL 

PROVIDER: S-EPMC6635377 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature