Ultra-fast genome comparison for large-scale genomic experiments.

ABSTRACT: In the last decade, a technological shift in the bioinformatics field has occurred: larger genomes can now be sequenced quickly and cost effectively, resulting in the computational need to efficiently compare large and abundant sequences. Furthermore, detecting conserved similarities across large collections of genomes remains a problem. The size of chromosomes, along with the substantial amount of noise and number of repeats found in DNA sequences (particularly in mammals and plants), leads to a scenario where executing and waiting for complete outputs is both time and resource consuming. Filtering steps, manual examination and annotation, very long execution times and a high demand for computational resources represent a few of the many difficulties faced in large genome comparisons. In

SUBMITTER: Perez-Wohlfeil E 

PROVIDER: S-EPMC6635410 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature