Musashi interaction with poly(A)-binding protein is required for activation of target mRNA translation.

ABSTRACT: The Musashi family of mRNA translational regulators controls both physiological and pathological stem cell self-renewal primarily by repressing target mRNAs that promote differentiation. In response to differentiation cues, Musashi can switch from a repressor to an activator of target mRNA translation. However, the molecular events that distinguish Musashi-mediated translational activation from repression are not understood. We have previously reported that Musashi function is required for the maturation of Xenopus oocytes and specifically for translational activation of specific dormant maternal mRNAs. Here, we employed MS to identify cellular factors necessary for Musashi-dependent mRNA translational activation. We report that Musashi1 needs to associate with the embryonic poly(A)

SUBMITTER: Cragle CE 

PROVIDER: S-EPMC6635449 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature