Lithium and GADL1 regulate glycogen synthase kinase-3 activity to modulate KCTD12 expression.

ABSTRACT: Potassium channel tetramerization domain containing 12 (KCTD12), the auxiliary GABA_B receptor subunit, is identified as a susceptibility gene for bipolar I (BPI) disorder in the Han Chinese population. Moreover, the single-nucleotide polymorphism (SNP) rs17026688 in glutamate decarboxylase-like protein 1 (GADL1) is shown to be associated with lithium response in Han Chinese BPI patients. In this study, we demonstrated for the first time the relationship among lithium, GADL1, and KCTD12. In circulating CD11b⁺ macrophage cells, BPI patients showed a significantly higher percentage of KCTD12 expression than healthy controls. Among BPI patients, carriers of the 'T' allele (i.e., CT or TT) at site rs17026688 were found to secrete lower amounts of GADL1 but higher amounts o

SUBMITTER: Wu TN 

PROVIDER: S-EPMC6635502 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature