Fully-automated radiosynthesis of the amyloid tracer [¹¹C] PiB via direct [¹¹C]CO₂ fixation-reduction.

ABSTRACT:

Background

The β-amyloid radiotracer [¹¹C] PiB is extensively used for the Positron Emission Tomography (PET) diagnosis of Alzheimer's Disease and related dementias. For clinical use, [¹¹C] PiB is produced using the ¹¹C-methylation method ([¹¹C] Methyl iodide or [¹¹C] methyl triflate as ¹¹C-methylation agents), which represents the most employed ¹¹C-labelling strategy for the synthesis of ¹¹C-radiopharmaceuticals. Recently, the use of direct [¹¹C]CO₂ fixation for the syntheses of ¹¹C-tracers has gained interest in the radiochemical community due to its importance in terms of radiochemical versatility and for permitting the direct employment of the cyclotron-produ

SUBMITTER: Buccino P 

PROVIDER: S-EPMC6635575 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature