Causal Association Between Birth Weight and Adult Diseases: Evidence From a Mendelian Randomization Analysis.

ABSTRACT: Purpose: Birth weight has a profound long-term impact on individual's predisposition to various diseases at adulthood-a hypothesis commonly referred to as the fetal origins of adult diseases. However, it is not fully clear to what extent the fetal origins of adult diseases hypothesis holds and it is also not completely known what types of adult diseases are causally affected by birth weight. Materials and methods: Mendelian randomization using multiple genetic instruments associated with birth weight was performed to explore the causal relationship between birth weight and adult diseases. The causal relationship between birth weight and 21 adult diseases as well as 38 other complex traits was examined based on data collected from 37 large-scale genome-wide association studies

SUBMITTER: Zeng P 

PROVIDER: S-EPMC6635582 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature