Assessing bioactivity-exposure profiles of fruit and vegetable extracts in the BioMAP profiling system.

ABSTRACT: The ToxCast program has generated in vitro screening data on over a thousand chemicals to assess potential disruption of important biological processes and assist in hazard identification and chemical testing prioritization. Few results have been reported for complex mixtures. To extend these ToxCast efforts to mixtures, we tested extracts from 30 organically grown fruits and vegetables in concentration-response in the BioMAP® assays. BioMAP systems use human primary cells primed with endogenous pathway activators to identify phenotypic perturbations related to proliferation, inflammation, immunomodulation, and tissue remodeling. Clustering of bioactivity profiles revealed separation of these produce extracts and ToxCast chemicals. Produce extracts elicited 87 assay endpoint responses per

SUBMITTER: Wetmore BA 

PROVIDER: S-EPMC6635950 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature