Cyclin-dependent kinase 5 acts as a promising biomarker in clear cell Renal Cell Carcinoma.

ABSTRACT:

Background

This research provides the first evidence of CDK5 in ccRCC prognosis and correlation with different p21 expression in overall survival (OS) analysis.

Methods

The data from both of The Cancer Genome Atlas (TCGA) and Gene Expression of Normal and Tumor Tissue (GENT) were analyzed for determining the expression of CDK5 in kidney cancer. Tissue microarray that made by using 150 ccRCC samples was used in immunohistochemistry (IHC) analysis. A validation of OS cohort was extracted from Oncomine database.

Results

The CDK5 expression was significantly lower in cancer tissue compared with normal in TCGA (p < 0.0001), GENT database also showed a relative low expression in kidney cancer. Among 150 ccRCC patients, low CDK5 was detected in 83 cases (55.3%), low p21 in 9

SUBMITTER: Zhu L 

PROVIDER: S-EPMC6636025 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature