Hyperinsulinemia promotes aberrant histone acetylation in triple-negative breast cancer.

ABSTRACT:

Background

Hyperinsulinemia, the presence of excess insulin relative to glucose in the blood, is considered to be a poor prognostic indicator for patients with triple-negative breast cancer (TNBC). mTOR, a downstream effector of insulin, enhances mitochondrial biogenesis and activity, thereby increasing acetyl-CoA precursors. Increased acetyl-CoA can, in turn, be utilized by nuclear acetyltransferases for histone acetylation, a critical feature of genome regulation. While signaling pathways downstream of insulin have been established for sometime, the effect of insulin on chromatin remains unclear. We hypothesized that hyperinsulinemia-induced metabolic changes lead to genome-wide changes in histone acetylation in TNBC.

Results

MDA-MB-231 cells were xenografted into hyperins

SUBMITTER: Senapati P 

PROVIDER: S-EPMC6636093 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature