Adaptive propensity score procedure improves matching in prospective observational trials.

ABSTRACT:

Background

Randomized controlled trials are the gold-standard for clinical trials. However, randomization is not always feasible. In this article we propose a prospective and adaptive matched case-control trial design assuming that a control group already exists.

Methods

We propose and discuss an interim analysis step to estimate the matching rate using a resampling step followed by a sample size recalculation. The sample size recalculation is based on the observed mean resampling matching rate. We applied our approach in a simulation study and to a real data set to evaluate the characteristics of the proposed design and to compare the results to a naive approach.

Results

The proposed design achieves at least 10% higher matching rate than the naive approach at final a

SUBMITTER: Weber D 

PROVIDER: S-EPMC6636117 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature