The association between pneumococcal vaccination, ethnicity, and the nasopharyngeal microbiota of children in Fiji.

ABSTRACT:

Background

Streptococcus pneumoniae is a significant global pathogen that colonises the nasopharynx of healthy children. Pneumococcal conjugate vaccines, which reduce nasopharyngeal colonisation of vaccine-type S. pneumoniae, may have broader effects on the nasopharyngeal microbiota; however, data are limited. In Fiji, nasopharyngeal carriage prevalence of S. pneumoniae and other colonising species differ between the two main ethnic groups. Here, we examined the association between the 7-valent pneumococcal conjugate vaccine (PCV7) and the nasopharyngeal microbiota of children in Fiji, including for each of the two main ethnic groups-indigenous Fijians (iTaukei) and Fijians of Indian descent (FID).

Method

The nasopharyngeal microbiota of 132 Fijian children was examined usin

SUBMITTER: Boelsen LK 

PROVIDER: S-EPMC6636143 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature