Systematic analysis of the lysine succinylome in the model medicinal mushroom Ganoderma lucidum.

ABSTRACT:

Background

Ganoderma lucidum, one of the best-known medicinal mushrooms in the world, produces more than 400 different bioactive compounds. However, the regulation of these bioactive compounds biosynthesis is still unclear. Lysine succinylation is a critical post-translational modification and has many important functions in all aspects of eukaryotic and prokaryotic cells. Although it has been studied for a long time, its function is still unclear in G. lucidum. In this study, a global investigation was carried out on the succinylome in G. lucidum.

Results

In total, 382 modified proteins which contain 742 lysine succinylated sites were obtained. The proteomics data are available through ProteomeXchange with the dataset accession number PXD013954. Bioinformatics analysis reve

SUBMITTER: Wang G 

PROVIDER: S-EPMC6636155 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature