Integrated identification of key genes and pathways in Alzheimer's disease via comprehensive bioinformatical analyses.

ABSTRACT:

Background

Alzheimer's disease (AD) is known to be caused by multiple factors, meanwhile the pathogenic mechanism and development of AD associate closely with genetic factors. Existing understanding of the molecular mechanisms underlying AD remains incomplete.

Methods

Gene expression data (GSE48350) derived from post-modern brain was extracted from the Gene Expression Omnibus (GEO) database. The differentially expressed genes (DEGs) were derived from hippocampus and entorhinal cortex regions between AD patients and healthy controls and detected via Morpheus. Functional enrichment analyses, including Gene Ontology (GO) and pathway analyses of DEGs, were performed via Cytoscape and followed by the construction of protein-protein interaction (PPI) network. Hub proteins were scr

SUBMITTER: Yan T 

PROVIDER: S-EPMC6636172 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature