A Bispecific Antibody-Based Approach for Targeting Mesothelin in Triple Negative Breast Cancer.

ABSTRACT: Triple negative breast cancers (TNBC) remain a major medical challenge due to poor prognosis and limited treatment options. Mesothelin is a glycosyl-phosphatidyl inositol-linked membrane protein with restricted normal expression and high level expression in a large proportion of TNBC, thus qualifying as an attractive target. Its overexpression in breast tumors has been recently correlated with a decreased disease-free survival and an increase of distant metastases. The objective of the study was to investigate the relevance of a bispecific antibody-based immunotherapy approach through mesothelin targeting and CD16 engagement using a Fab-like bispecific format (MesobsFab). Using two TNBC cell lines with different level of surface mesothelin and epithelial/mesenchymal phenotypes, we showed t

SUBMITTER: Del Bano J 

PROVIDER: S-EPMC6636429 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature