Schwann Cell-Like Cells Derived from Human Amniotic Mesenchymal Stem Cells Promote Peripheral Nerve Regeneration through a MicroRNA-214/c-Jun Pathway.

ABSTRACT:

Background

The use of Schwann cell-like cells (SCLCs) derived from stem cells has been introduced as an effective strategy for promoting peripheral nerve regeneration (PNR). However, molecular mechanisms underlying therapeutic transplantation of SCLCs for PNR are often ignored.

Objectives

To explore the potential of SCLCs for the treatment of sciatic never injury and investigate the underlying molecule mechanisms.

Method

SCLCs differentiated from human amniotic mesenchymal stem cells (hAMSCs) and specific markers of Schwann cells were detected. SCLCs were transplanted into the injured sites of a rat model of sciatic nerve injury, and sciatic nerve functional index (SFI) was determined.

Results

SCLCs expressed specific markers of Schwann cells as well as secrete

SUBMITTER: Chen W 

PROVIDER: S-EPMC6636479 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature