Genetic testing for prevention of severe drug-induced skin rash.
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ABSTRACT:
SUBMITTER: Alfirevic A
PROVIDER: S-EPMC6636675 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Publications
Genetic testing for prevention of severe drug-induced skin rash.
Alfirevic Ana A Pirmohamed Munir M Marinovic Branka B Harcourt-Smith Linda L Jorgensen Andrea L AL Cooper Tess E TE
The Cochrane database of systematic reviews 20190717
<h4>Background</h4>Drug-induced skin reactions present with a range of clinical symptoms, from mild maculopapular skin rashes to potentially fatal blistering skin rashes - such as Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) - which may result in death. Milder reactions may be troublesome and lead to low drug compliance. The pathogenesis of these drug reactions is not yet fully understood; however, there is evidence that pretreatment genetic testing may help to predict and ...[more]
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