Determining population stratification and subgroup effects in association studies of rare genetic variants for nicotine dependence.

ABSTRACT:

Background

Rare variants (minor allele frequency < 1% or 5 %) can help researchers to deal with the confounding issue of 'missing heritability' and have a proven role in dissecting the etiology for human diseases and complex traits.

Methods

We extended the combined multivariate and collapsing (CMC) and weighted sum statistic (WSS) methods and accounted for the effects of population stratification and subgroup effects using stratified analyses by the principal component analysis, named here as 'str-CMC' and 'str-WSS'. To evaluate the validity of the extended methods, we analyzed the Genetic Architecture of Smoking and Smoking Cessation database, which includes African Americans and European Americans genotyped on Illumina Human Omni2.5, and we compared the results with those

SUBMITTER: Hsieh AR 

PROVIDER: S-EPMC6636808 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature