Differential Sensitivity to IL-12 Drives Sex-Specific Differences in the CD8+ T Cell Response to Infection.

ABSTRACT: It is well known that males and females respond differently to intracellular pathogens. Females mount a more robust immune response than males, which decreases their susceptibility to infection but comes at the cost of increasing immunopathology. However, the underlying basis for sex-specific differences in the CD8⁺ T cell response to infection remains poorly understood. In this study, we show that female CD8⁺ T cells have an intrinsic propensity to become short-lived effectors, whereas male CD8⁺ T cells give rise to more memory precursor effector cells after murine infection with either a virus (vaccinia virus) or bacteria (Listeria monocytogenes). Interestingly, we found that the propensity of female CD8⁺ T cells to form short-lived effe

SUBMITTER: Yee Mon KJ 

PROVIDER: S-EPMC6636834 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature