Risk of HIV-1 acquisition among South African women using a variety of contraceptive methods in a prospective study.

ABSTRACT:

Objective

Observational studies have associated use of intramuscular injectable depot medroxyprogesterone acetate (DMPA-IM) with increased risk of HIV-1 acquisition, but limited data are available to assess HIV-1 risk for alternate contraceptive methods.

Methods

Within a randomized trial of the dapivirine vaginal ring for HIV-1 prevention, we assessed HIV-1 incidence by contraceptive method. We limited analyses to participants from South African sites and to women who used DMPA-IM, the alternative injectable norethisterone enanthate, implants, or copper intrauterine devices (IUDs). Contraceptive method was assessed as a time-dependent exposure and multivariate models adjusted for trial randomization arm, age, sexual behaviour, and incident sexually transmitted infections.

SUBMITTER: Palanee-Phillips T 

PROVIDER: S-EPMC6636847 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature