Systematic review and case series: flexible sigmoidoscopy identifies most cases of checkpoint inhibitor-induced colitis.

ABSTRACT:

Background

Immune checkpoint inhibitors are used in the treatment of multiple advanced stage cancers but can induce immune-mediated colitis necessitating treatment with immunosuppressive medications. Diagnostic colonoscopy is often performed but requires bowel preparation and may delay diagnosis and treatment. Sigmoidoscopy can be performed rapidly without oral bowel preparation or sedation.

Aims

Characterize the colonic distribution of immune-mediated colitis to determine the most efficient endoscopic approach.

Methods

A systematic review of checkpoint inhibitor-induced colitis case reports and series was conducted in both PubMed and Embase through 3 January 2017. A single centre retrospective chart review of patients who underwent endoscopic evaluation for diarrhoea

SUBMITTER: Wright AP 

PROVIDER: S-EPMC6637018 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature