Ontology highlight
ABSTRACT:
SUBMITTER: Yoshida M
PROVIDER: S-EPMC6637122 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Nature communications 20190717 1
Ferroptosis is a necrotic form of regulated cell death (RCD) mediated by phospholipid peroxidation in association with free iron-mediated Fenton reactions. Disrupted iron homeostasis resulting in excessive oxidative stress has been implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD). Here, we demonstrate the involvement of ferroptosis in COPD pathogenesis. Our in vivo and in vitro models show labile iron accumulation and enhanced lipid peroxidation with concomitant non ...[more]