Speckle modulation enables high-resolution wide-field human brain tumor margin detection and in vivo murine neuroimaging.

ABSTRACT: Current in vivo neuroimaging techniques provide limited field of view or spatial resolution and often require exogenous contrast. These limitations prohibit detailed structural imaging across wide fields of view and hinder intraoperative tumor margin detection. Here we present a novel neuroimaging technique, speckle-modulating optical coherence tomography (SM-OCT), which allows us to image the brains of live mice and ex vivo human samples with unprecedented resolution and wide field of view using only endogenous contrast. The increased visibility provided by speckle elimination reveals white matter fascicles and cortical layer architecture in brains of live mice. To our knowledge, the data reported herein represents the highest resolution imaging of murine white matter structure achieved i

SUBMITTER: Yecies D 

PROVIDER: S-EPMC6637128 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature