Ursodeoxycholic acid accelerates bile acid enterohepatic circulation.

ABSTRACT:

Background and purpose

Ursodeoxycholic acid (UDCA) is the first-line treatment for primary biliary cholangitis, but its effects on the enterohepatic circulation of bile acid (BA) have been under-investigated. Therefore, we studied the influence of UDCA on BA enterohepatic circulation in vivo and the mechanisms by which UDCA affects the BA kinetics.

Experimental approach

Mice were treated with UDCA and other BAs to observe changes in BA pool and BA transporters involved in enterohepatic circulation. Isotope dilution techniques and biochemical analyses were applied to study BA kinetics after oral administration of UDCA, and the mechanism involved.

Key results

Oral administration of UDCA in mice reduced the overall BA pool and produced a unique BA profile with high-abund

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC6637225 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature