Vitamin D metabolic loci and vitamin D status in Black and White pregnant women.

ABSTRACT:

Background

Several candidate genes and genome wide association studies have reported significant associations between vitamin D metabolism genes and 25-hydroxyvitamin D. Few studies have examined these relationships in pregnancy.

Objective

We evaluated the relationship between maternal allelic variants in three vitamin D metabolism genes and 25-hydroxyvitamin D (25(OH)D) concentration in pregnancy.

Study design

In two case-control studies, samples were drawn from women who delivered at Magee Womens Hospital in Pittsburgh, PA from 1999 to 2010 and twelve recruiting sites across the United States from 1959 to 65. For 882 Black and 1796 White pregnant women from these studies, 25(OH)D concentration was measured and single nucleotide polymorphisms (SNPs) were genotyped 50

SUBMITTER: Baca KM 

PROVIDER: S-EPMC6637415 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature