Route of Infection Strongly Impacts the Host-Pathogen Relationship.

ABSTRACT: Live attenuated vaccines play a key role in the control of many human and animal pathogens. Their rational development is usually helped by identification of the reservoir of infection, the lymphoid subpopulations associated with protective immunity as well as the virulence genes involved in pathogen persistence. Here, we compared the course of Brucella melitensis infection in C57BL/6 mice infected via intraperitoneal (i.p.), intranasal (i.n.) and intradermal (i.d.) route and demonstrated that the route of infection strongly impacts all of these parameters. Following i.p. and i.n. infection, most infected cells observed in the spleen or lung were F4/80⁺ myeloid cells. In striking contrast, infected Ly6G⁺ neutrophils and CD140a⁺ fibroblasts were also

SUBMITTER: Demars A 

PROVIDER: S-EPMC6637429 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature