Meta-analysis of GWA studies provides new insights on the genetic architecture of skin pigmentation in recently admixed populations.

ABSTRACT:

Background

Association studies in recently admixed populations are extremely useful to identify the genetic architecture of pigmentation, due to their high genotypic and phenotypic variation. However, to date only four Genome-Wide Association Studies (GWAS) have been carried out in these populations.

Results

We present a GWAS of skin pigmentation in an admixed sample from Cuba (N = 762). Additionally, we conducted a meta-analysis including the Cuban sample, and admixed samples from Cape Verde, Puerto Rico and African-Americans from San Francisco. This meta-analysis is one of the largest efforts so far to characterize the genetic basis of skin pigmentation in admixed populations (N = 2,104). We identified five genome-wide significant regions in the meta-analysis, and explored

SUBMITTER: Lona-Durazo F 

PROVIDER: S-EPMC6637524 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature