MTORC1/AMPK responses define a core gene set for developmental cell fate switching.

ABSTRACT:

Background

Kinases mTORC1 and AMPK act as energy sensors, controlling nutrient responses and cellular growth. Changes in nutrient levels affect diverse transcriptional networks, making it challenging to identify downstream paths that regulate cellular growth or a switch to development via nutrient variation. The life cycle of Dictyostelium presents an excellent model to study the mTORC1 signaling function for growth and development. Dictyostelium grow as single cells in nutrient-rich media, but, upon nutrient withdrawal, growth ceases and cells enter a program for multi-cell development. While nearly half the genome shows gene expression changes upon nutrient removal, we hypothesized that not all of these genes are required for the switch to program development. Through manipulatio

SUBMITTER: Jaiswal P 

PROVIDER: S-EPMC6637605 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature