Biomarkers for diagnosing serious bacterial infections in older outpatients: a systematic review.

ABSTRACT:

Background

The value of biomarkers for diagnosing bacterial infections in older outpatients is uncertain and limited official guidance exists for clinicians in this area. The aim of this review is to critically appraise and evaluate biomarkers for diagnosing bacterial infections in older adults (aged 65 years and above).

Methods

We searched Medline, Embase, Web of Science and the Cochrane Library, from inception to January 2018. We included studies assessing the diagnostic accuracy of blood, urinary, and salivary biomarkers in diagnosing bacterial infections in older adults. The QUADAS-2 tool was used to assess study quality.

Results

We identified 11 eligible studies of moderate quality (11,034 participants) including 51 biomarkers at varying thresholds for diagnosing

SUBMITTER: Gbinigie OA 

PROVIDER: S-EPMC6637629 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature