Exosome-mimetic nanoplatforms for targeted cancer drug delivery.

ABSTRACT:

Background

Lack of effective tumor-specific delivery systems remains an unmet clinical challenge for successful translation of innovative therapies, such as, therapeutic oligonucleotides. In the past decade, exosomes have been suggested to be ideal drug delivery systems with application in a broad range of pathologies including cancer, due to their organotropic properties. Tumor-derived exosomes, having tumor-homing properties, can efficiently reach cancer cells and therefore behave as carriers for improved drug delivery to the primary tumor and metastases. However, due to their complex composition, and still undefined biological functions, safety concerns arise hampering their translation to the clinics.

Results

We propose here the development of exosome-mimetic nanosystems

SUBMITTER: Vazquez-Rios AJ 

PROVIDER: S-EPMC6637649 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature