The HCPro from the Potyviridae family: an enviable multitasking Helper Component that every virus would like to have.

ABSTRACT: RNA viruses have very compact genomes and so provide a unique opportunity to study how evolution works to optimize the use of very limited genomic information. A widespread viral strategy to solve this issue concerning the coding space relies on the expression of proteins with multiple functions. Members of the family Potyviridae, the most abundant group of RNA viruses in plants, offer several attractive examples of viral factors which play roles in diverse infection-related pathways. The Helper Component Proteinase (HCPro) is an essential and well-characterized multitasking protein for which at least three independent functions have been described: (i) viral plant-to-plant transmission; (ii) polyprotein maturation; and (iii) RNA silencing suppression. Moreover, multitudes of host factors

SUBMITTER: Valli AA 

PROVIDER: S-EPMC6638112 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature