Fungal attack and host defence pathways unveiled in near-avirulent interactions of Penicillium expansum creA mutants on apples.

ABSTRACT: Amongst the universal diseases affecting apples, blue mould caused by Penicillium expansum is a major concern, resulting in yield and quality losses as a result of the production of the mycotoxin patulin. Despite the characterization of the patulin biosynthetic gene cluster at both the molecular and chemical levels, the underlying regulation of patulin biosynthesis in P. expansum and the mechanisms of apple colonization remain largely obscure. Recent work has indicated that sucrose, a carbon catabolite repressive metabolite, is a critical factor in the regulation of patulin synthesis. Here, CreA, the global carbon catabolite regulator, was assessed for virulence both in vitro and in vivo. We showed that loss-of-function creA strains were nearly avirulent and did not produce patulin in appl

SUBMITTER: Tannous J 

PROVIDER: S-EPMC6638163 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature