Genome-wide characterization of Phytophthora infestans metabolism: a systems biology approach.

ABSTRACT: Genome-scale metabolic models (GEMs) provide a functional view of the complex network of biochemical reactions in the living cell. Initially mainly applied to reconstruct the metabolism of model organisms, the availability of increasingly sophisticated reconstruction methods and more extensive biochemical databases now make it possible to reconstruct GEMs for less well-characterized organisms, and have the potential to unravel the metabolism in pathogen-host systems. Here, we present a GEM for the oomycete plant pathogen Phytophthora infestans as a first step towards an integrative model with its host. We predict the biochemical reactions in different cellular compartments and investigate the gene-protein-reaction associations in this model to obtain an impression of the biochemical capabi

SUBMITTER: Rodenburg SYA 

PROVIDER: S-EPMC6638193 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature