LaeA regulation of secondary metabolism modulates virulence in Penicillium expansum and is mediated by sucrose.

ABSTRACT: Penicillium expansum, the causal agent of blue mould rot, is a critical health concern because of the production of the mycotoxin patulin in colonized apple fruit tissue. Although patulin is produced by many Penicillium species, the factor(s) activating its biosynthesis are not clear. Sucrose, a key sugar component of apple fruit, was found to modulate patulin accumulation in a dose-responsive pattern. An increase in sucrose culture amendment from 15 to 175 mm decreased both patulin accumulation and expression of the global regulator laeA by 175- and five-fold, respectively, whilst increasing expression of the carbon catabolite repressor creA. LaeA was found to regulate several secondary metabolite genes, including the patulin gene cluster and concomitant patulin synthesis in vitro. Virule

SUBMITTER: Kumar D 

PROVIDER: S-EPMC6638289 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature