Increased expression of blood muscarinic receptors in patients with reflex syncope.

ABSTRACT:

Aims

Pathophysiology of reflex syncope is not fully understood but a vagal overactivity might be involved in this syncope. Previously, overexpression of muscarinic M2 receptors and acetylcholinesterase was found in particular in the heart and in lymphocytes of rabbits with vagal overactivity as well as in hearts of Sudden Infant Death Syndromes. The aim of this present study was to look at M2 receptor expression in blood of patients with reflex syncope. The second objective was to measure acetylcholinesterase expression in these patients.

Methods and results

136 subjects were enrolled. This monocenter study pooled 45 adults exhibiting recurrent reflex syncope compared with 32 healthy adult volunteers (18-50 years) and 38 children exhibiting reflex syncope requiring hospitali

SUBMITTER: Beutelstetter M 

PROVIDER: S-EPMC6638918 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature