Influence of genetic variation in the vitamin D pathway on plasma 25-hydroxyvitamin D₃ levels and survival among patients with metastatic colorectal cancer.

ABSTRACT:

Purpose

The relationships of genetic variation in the vitamin D pathway with circulating 25-hydroxyvitamin D₃ [25(OH)D] levels and survival remain largely unknown for patients with metastatic colorectal cancer (mCRC).

Methods

Among 535 patients participating in a randomized trial of chemotherapy for mCRC, we prospectively measured baseline plasma 25(OH)D and examined 124 tagging single-nucleotide polymorphisms (SNPs) within seven genes in the vitamin D pathway, including five SNPs associated with circulating 25(OH)D levels in previous genome-wide association studies (GWAS). We evaluated whether these SNPs were associated with plasma 25(OH)D levels and patient outcome (overall survival, time to progression, and tumor response), using linear, logistic, and Cox propo

SUBMITTER: Yuan C 

PROVIDER: S-EPMC6639016 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature