Gut epithelial and vascular barrier abnormalities in patients with chronic intestinal pseudo-obstruction.

ABSTRACT:

Background

Chronic intestinal pseudo-obstruction (CIPO) is a rare condition due to severe impairment of gut motility responsible for recurrent subocclusive episodes. Although neuromuscular-glial-ICC abnormalities represent the main pathogenetic mechanism, the pathophysiology of CIPO remains poorly understood. Intestinal epithelial and vascular endothelial barrier (IEVB) abnormalities can contribute to neuroepithelial changes by allowing passage of harmful substances.

Methods

To test retrospectively whether IEVB defects occur in patients with CIPO, we measured the jejunal protein expression of the major tight junction (TJ) components. CIPO patients were subdivided according to gut neuromuscular histopathology: apparently normal (AN); with inflammation (INF); or with degenerat

SUBMITTER: Boschetti E 

PROVIDER: S-EPMC6639131 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature