Tailored cell sheet engineering using microstereolithography and electrochemical cell transfer.

ABSTRACT: Postoperative adhesion and occlusion remain a serious issue associated with various surgeries, including endoscopic surgery, in which proliferated fibrous tissues stick to adjacent tissues and often cause severe complications. Cell sheet engineering has emerged as an effective approach not only for cell transplantation but also for the treatment of postoperative adhesion and occlusion. However, as the tissues in the body, such as middle ear and small intestine, and typical operative sites are non-flat and spatially complicated, tailored cell sheets with three-dimensional (3D) configurations may lead to widespread use of this approach. In the present study, we used microstereolithography, biocompatible gold plating, and electrochemical cell detachment to achieve this purpose. Various object

SUBMITTER: Kobayashi Y 

PROVIDER: S-EPMC6639316 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature