Genome and epigenome wide studies of neurological protein biomarkers in the Lothian Birth Cohort 1936.

ABSTRACT: Although plasma proteins may serve as markers of neurological disease risk, the molecular mechanisms responsible for inter-individual variation in plasma protein levels are poorly understood. Therefore, we conduct genome- and epigenome-wide association studies on the levels of 92 neurological proteins to identify genetic and epigenetic loci associated with their plasma concentrations (n = 750 healthy older adults). We identify 41 independent genome-wide significant (P < 5.4 × 10^-10) loci for 33 proteins and 26 epigenome-wide significant (P < 3.9 × 10^-10) sites associated with the levels of 9 proteins. Using this information, we identify biological pathways in which putative neurological biomarkers are implicated (neurological, immunological and extracellular matrix me

SUBMITTER: Hillary RF 

PROVIDER: S-EPMC6639385 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature