Cellular Senescence and the Kidney: Potential Therapeutic Targets and Tools.

ABSTRACT: Chronic kidney disease (CKD) is an increasing health burden (affecting approximately 13.4% of the population). Currently, no curative treatment options are available and treatment is focused on limiting the disease progression. The accumulation of senescent cells has been implicated in the development of kidney fibrosis by limiting tissue rejuvenation and through the secretion of pro-fibrotic and pro-inflammatory mediators termed as the senescence-associated secretory phenotype. The clearance of senescent cells in aging models results in improved kidney function, which shows promise for the options of targeting senescent cells in CKD. There are several approaches for the development of "senotherapies", the most rigorous of which is the elimination of senescent cells by the so-called senoly

SUBMITTER: Knoppert SN 

PROVIDER: S-EPMC6639430 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature