Effectiveness of postoperative radiotherapy after radical cystectomy for locally advanced bladder cancer.

ABSTRACT:

Background

Local-regional failure (LF) for locally advanced bladder cancer (LABC) after radical cystectomy (RC) is common even with chemotherapy and is associated with high morbidity/mortality. Postoperative radiotherapy (PORT) can reduce LF and may enhance overall survival (OS) but has no defined role. We hypothesized that the addition of PORT would improve OS in LABC in a large nationwide oncology database.

Methods

We identified ≥ pT3pN0-3M0 LABC patients in the National Cancer Database diagnosed 2004-2014 who underwent RC ± PORT. OS was calculated using Kaplan-Meier and Cox proportional hazards regression modeling was used to identify predictors of OS. Propensity matching was performed to match RC patients who received PORT vs those who did not.

Results

15,124 RC p

SUBMITTER: Fischer-Valuck BW 

PROVIDER: S-EPMC6639450 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature