Fecal short-chain fatty acid concentrations and dysbiosis in dogs with chronic enteropathy.

ABSTRACT:

Background

Accumulating evidence shows an important relationship between the gastrointestinal (GI) microbiota and host health. Microbial metabolites are believed to play a critical role in host-microbial interactions. Short-chain fatty acids (SCFAs) are major end products of bacterial carbohydrate fermentation in the intestinal tract. Decreased concentrations of SCFAs have been observed in humans with GI disease. However, large-scale clinical data in dogs are lacking.

Hypothesis/objective

To evaluate fecal concentrations of SCFAs and the fecal microbiota in healthy control (HC) dogs and dogs with chronic enteropathy (CE).

Animals

Forty-nine privately owned HC dogs and 73 dogs with CE.

Methods

Prospective cohort study. Fecal concentrations of SCFAs were measured

SUBMITTER: Minamoto Y 

PROVIDER: S-EPMC6639498 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature